Looking for Tumor Specific Promoters In Silico

Abstract— Previously we demonstrated the tumor-specific activity of several human native and chimeric promoters. Here have analyzed DNA sequences experimentally tested promoters for presence recognition matrices transcription factors de novo motif discovery. CiiiDER MEME Suite software tools were used this purpose. A number factor been identified, which are present more often in than housekeeping genes. New promoter–TF regulatory relationships predicted by pathway analysis. 44 bp characteristic but not gene has discovered. The search through 29 598 from EPDnew promoter database revealed a series with motif, their genes being associated unfavorable prognoses cancer. We suppose that some these may possess tumor specific activity. In addition, close similarity nucleotide motifs between BIRC5 MCM2 shown. results study contribute to understanding peculiarities tumors, as well searching or creating artificial ones cancer therapy, development anticancer vaccines.